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Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive

Paul D. Curtis·M. E. Richmond·L.A. Miller·F.W. Quimby
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Abstract

White-tailed deer (n = 14 treated, n = 7 control) were examined postmortem to identify any possible pathophysiology resulting from PZP immunocontraception vaccination. Deer were treated twice in 1997; given a booster in 1998, with six being revaccinated in September 2000. Granulomas were found at injection sites of most deer, even 2 years post-treatment. Eosinophilic oophoritis occurred in 6 of 8 (75%) deer vaccinated in 1998, and 3 of 6 (50%) revaccinated in 2000. The 2000 revaccinates without oophoritis, had significantly fewer normal secondary follicles than control females (P = 0.03), and deer in the1998 treatment group (P = 0.04). PZP immunocontraceptive vaccine elicited ovarian pathologies in deer similar to those observed in other species. ?? 2007 Elsevier Ltd. All rights reserved.

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Paul D. Curtis, M. E. Richmond, L.A. Miller, F.W. Quimby. 2007. Pathophysiology of white-tailed deer vaccinated with porcine zona pellucida immunocontraceptive. https://doi.org/10.1016/j.vaccine.2007.03.033

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