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Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout

T.D. Hubert·J.A. Bernardy·C. Vue·V. K. Dawson·M.A. Boogaard·Theresa M. Schreier·W.H. Gingerich
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Abstract

Rainbow trout (Oncorhyncus mykiss) were exposed to the 14C- labeled lampricide 3-trifluoromethyl-4-nitrophenol (TFM) (2.1 mg/L) or niclosamide (0.055 mg/L) in an aerated static water bath for 24 h. Fish were sacrificed immediately after exposure. Subsamples of skin-on muscle tissue were analyzed for residues of the lampricides. The primary residues in muscle tissue from fish exposed to TFM were parent TFM (1.08 ?? 0.82 nmol/g) and TFM-glucuronide (0.44 ?? 0.24 nmol/g). Muscle tissue from fish exposed to niclosamide contained niclosamide (1.42 ?? 0.51 nmol/g), niclosamide-glucuronide (0.0644 ?? 0.0276 nmol/g), and a metabolite not previously reported, niclosamide sulfate ester (1.12 ?? 0.33 nmol/g).

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T.D. Hubert, J.A. Bernardy, C. Vue, V. K. Dawson, M.A. Boogaard, Theresa M. Schreier, W.H. Gingerich. 2005-05-27. Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout. https://doi.org/10.1021/jf050156o

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