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Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system

Jeffery R. Meinertz·Theresa M. Schreier·Jeffry A. Bernardy·Jeanne L. Franz
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Abstract

Diphenhydramine hydrochloride (DH; Benadryl™, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 μg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 μg/L for 21 days did not significantly impact D . magna survival and production. In this study the no observable effect concentration for DH was 0.12 μg/L and for ET was 248 μg/L.

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Jeffery R. Meinertz, Theresa M. Schreier, Jeffry A. Bernardy, Jeanne L. Franz. 2010-10-23. Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system. https://doi.org/10.1007/s00128-010-0117-7

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