A receptor binding assay applied to monitoring the neurotoxicity of parathion to Peromyscus after oral exposure

David A. Jett; A.T. Eldefrawi; M.E. Eldefrawi

doi:10.1520/stp13159s

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A receptor binding assay applied to monitoring the neurotoxicity of parathion to Peromyscus after oral exposure

David A. Jett·A.T. Eldefrawi·M.E. Eldefrawi

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Abstract

Many naturally occurring toxins, as well as pesticides, metals, and other compounds that occur in our environment from anthropogenic activities, stimulate or antagonize neuro-receptors to produce acute and/or chronic toxicities. Recent advances in laboratory instrumentation and the availability of a variety of radiolabeled ligands and type-specific drugs for numerous receptors make it possible to easily screen large numbers of samples and detect changes in sensitivity and density of receptor types and subtypes. A receptor binding assay for examining the chronic dietary toxicity of parathion will be used as a model to describe the methodology.

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David A. Jett, A.T. Eldefrawi, M.E. Eldefrawi. 1993. A receptor binding assay applied to monitoring the neurotoxicity of parathion to Peromyscus after oral exposure. https://doi.org/10.1520/stp13159s

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